? OVERVIEW

CoQ10 (Coenzyme Q10) is a natural antioxidant synthesized by the body, found in many foods, and is available as a supplement.  It comes in two forms: ubiquinol, the active antioxidant form, and ubiquinone, the oxidized form, which the body partially converts to ubiquinol.  Many multi-ingredient supplements contain both forms.

In general, coenzymes support enzymes in their various biochemical functions.  CoQ10 is a vital participant in the chain of metabolic chemical reactions that generate energy within cells.  It is found in every cell of the body (the name ubiquinone stems from its ubiquity), but is present in higher concentrations in organs with higher energy requirements such as the kidneys, liver, and heart.

It is this very relationship of CoQ10 with the heart organ itself that this study is being performed.

Myocardial infarction (MI), or heart attack as it is more commonly known, due to sudden occlusion of a major coronary artery leads to a complex series of events that result in left ventricle (LV) impairment and eventual heart failure.  The aim of this study was to compare the acute cardioprotective effects and/or benefits of the antioxidants, resveratrol (RES) and coenzyme Q10 (CoQ10).

? CoQ10 STUDY

A study was performed on male Wistar rats to compare the acute heart protective effects of the antioxidants, resveratrol and coenzyme Q10, either individually or in combination in rats with heart experimentally induced heart attacks.

? RESULTS

Compared to resveratrol alone, coenzyme Q10, either by itself or in combination with resveratrol, significantly reduced the infarct area of the heart (57%), and normalized physiological parameters of the heart.  CoQ10 also decreased blood levels of various circulating inflammatory markers like TNF-? (83.2%) and IL-6 (83.2%).

? CONCLUSION

Coenzyme Q10 definitively protects against the acute sequelae of myocardial infarction.  It profoundly reduced infarct area, inflammation and oxidative stress while normalizing left ventricle bloodflow after an infarction.

? REFERENCE

http://www.ncbi.nlm.nih.gov/pubmed/26069524