Most cancers were always thought to be an accumulation of avoidable toxic and chemical factors until a recent study in Science suggested that cancer risk may heavily be due to intrinsic, unavoidable risk factors.


To assess whether the correction to the development of cancer is due to unavoidable intrinsic risks, the so called ‘bad luck’ hypothesis.


Researchers in this study published in Nature, demonstrate that the correlation between stem-cell division and cancer risk does not differ between the effects of intrinsic and extrinsic factors. In fact, their results showed that intrinsic risk is better calculated by the lower bound risk controlling for total stem-cell divisions.

These results conclude that cancer risk is very much influenced by extrinsic factors.