Alzheimer’s disease is a common cause of dementia, and is increasing at a dramatic rate.


323 studies that were completed between 1968 and 2014 were reviewed to assess factors that are protective and non-protective to developing Alzheimer’s.


The following had the strongest evidence of reducing the risk of the disease:

  • coffee
  • nonsteroidal anti-inflammatory drugs
  • statins
  • antihypertensive medications
  • vitamins C
  • vitamin E
  • folate
  • estrogen supplementation.

The following factors increased the risks of the disease:

  • high blood pressure
  • depression
  • high body mass index in midlife
  • carotid artery disease
  • frailty
  • being poorly educated
  • having high levels of homocysteine
  • being a smoker and/or having type 2 diabetes.


The authors write:

The current evidence from our study showed that individuals would benefit from addressing the related potentially modifiable risk factors.