Systemic lupus erythematosus (SLE) is a systemic autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue.  The most common type is systemic lupus erythematosus (SLE), which affects many internal organs in the body.  SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system.  The course of the disease is unpredictable, with periods of illness  alternating with remissions.

The purpose of this study is to see how SLE affects women of reproductive age – when pregnancy is a major concern and family priority, and to identify predictors of Adverse Pregnancy Outcomes (APOs) in patients with inactive, stable or active SLE.

? Lupus Study

385 patients with SLE were utilized during the study.  Various APOs included fetal or infant death; premature birth, hypertension; and low birthweight.  Disease activity was assessed with the Systemic Lupus Erythematosus Pregnancy Disease Activity Index.

? Conclusion

APOs occurred in 19.0% of SLE pregnancies; fetal death occurred in 4%, neonatal death occurred in 1%, preterm delivery occurred in 9%, and SGA neonate occurred in 10%.

Severe flares in the second and third trimesters occurred in 2.5% and 3.0%, respectively.  So in conclusion, pregnant patients with inactive or stable mild/moderate SLE, severe flares are infrequent and outcomes are generally favorable.

? Reference